I'm sure we all knew this has been coming...I doubt it's the 'first' but perhaps first publicly acknowledged.

Quote:The first fully A.I.-generated drug enters clinical trials in human patients

Key Points

• Insilico Medicine, a Hong Kong-based biotech startup with more than $400 million in funding, created the drug as a treatment for idiopathic pulmonary fibrosis, a chronic lung disease.
  
  
• "It is the first fully generative AI drug to reach human clinical trials, and specifically Phase II trials with patients," Alex Zhavoronkov, founder and CEO of Insilico Medicine, told CNBC.
  
  
• The discovery process for the new drug began in 2020.
  

Insilico Medicine, a Hong Kong-based biotech startup with more than $400 million in funding, created the drug, INS018_055, as a treatment for idiopathic pulmonary fibrosis, a chronic disease that causes scarring in the lungs. The condition, which has increased in prevalence in recent decades, currently affects about 100,000 people in the U.S. and can lead to death within two to five years if untreated, according to the National Institutes of Health.

"It is the first fully generative AI drug to reach human clinical trials, and specifically Phase II trials with patients," Alex Zhavoronkov, founder and CEO of Insilico Medicine, told CNBC. "While there are other AI-designed drugs in trials, ours is the first drug with both a novel AI-discovered target and a novel AI-generated design." 

The discovery process for the new drug began in 2020, with hopes to create a "moonshot" medicine to overcome challenges with current treatments for the condition, which mostly focus on slowing progression and can cause uncomfortable side effects, Zhavoronkov said.

He added that Insilico has chosen to focus on IPF in part because of the condition's implications in aging, but the company has two other drugs partially generated by AI in the clinical stage. One is a Covid-19 drug in phase one clinical trials, and the other is a cancer drug, specifically a "USP1 inhibitor for the treatment of solid tumors," that recently received FDA approval to initiate clinical trials.

When this company was launched, we were focused on algorithms — developing the technology that could discover and design new molecules," Zhavoronkov said. "I never imagined in those early days that I would be taking my own AI drugs into clinical trials with patients. But we realized that in order to validate our AI platform, we needed to not only design a new drug for a new target, but bring it into clinical trials to prove that our technology worked." 

The IPF drug's current study is a randomized, double-blind, placebo-controlled trial taking place over 12 weeks in China, and Insilico has plans to expand the testing population to 60 subjects at 40 sites in the U.S. and China. If the current phase two study is successful, it will go on to another study with a larger cohort, and then potentially reach phase three studies with hundreds of participants.

"We expect to have results from the current Phase II trial next year," Zhavoronkov said, adding that it's difficult to predict exact timing for future phases, especially since the disease is relatively rare and patients must fulfill specific criteria. He added, "We are optimistic that this drug will be ready for market, and reach patients who may benefit from it, in the next few years." 

Quote:“And in May, we announced that our first AI-designed cancer drug received IND approval from the FDA to proceed to clinical trials – a new treatment for solid tumors that shows promise to benefit cancer patients who are resistant to other treatments. “

Zhavoronkov also added: “We have a number of cancer drugs designed by AI in our pipeline, and presented four of them at the American Association for Cancer Research annual meeting in Orlando, Florida held in April.”

About the role of the Abu Dhabi research lab in developing this test drug for IPF, Zhavoronkov, said: “Our AI and Quantum Computing R&D center in Abu Dhabi drives the technology advancements related to our generative AI platform, Pharma.AI, which combines generative chemistry and generative biology in order to produce new drugs like this IPF drug.”

“This platform was used in order to identify the novel target (known as “Target X”) which is implicated not only in IPF but other forms of fibrosis, and was also used to generate an entirely new molecule which has shown promise as a treatment for IPF and is now in Phase II trials with patients.
....
Zhavoronkov added: “We see great potential for continued use of the AlphaFold predicted protein database with our platform. We’ve also added chat functionality into our target discovery engine, called ChatPandaGPT, allowing users more seamless interaction with the knowledge graph that connects diseases and possible targets. And in another international collaboration, we also recently published a study combining quantum computing with generative chemistry to generate new molecules. It’s the first step in what we believe will be the future of drug discovery and was published in the Journal of Chemical Information and Modeling.”

Insilico takes AI-discovered designer drug into trials to treat pulmonary fibrosis

Quote:Dating AI is "a meditation on how to prepare for the unknown," a thought experiment designed to stimulate new ideas about issues that are important now as well as in the future. Fictional descriptions of human-android romances are interspersed with commentary about the varying differences between people and AI (Artificial Intelligence), and methods for breaching the chasm between machine and human experience. Chapters tie speculation into contemporary life, drawing parallels between current human interactions with machines.

Section 1, "Are you ready to fall in love with a machine?" explains what you'll need to know to engage romantically with AI (including similarities and differences). Section 2, "You are ready, now what?" helps interested humans prepare to date AI. Section 3, "Establishing a relationship" covers the complicated mix of human and AI needs in a relationship, including power dynamics and acceptable behavior. Section 4, "Getting over a breakup (or merger)" explains some of the legal and economic fallout that could result from the demise of an human-AI breakup.

Dating AI is an entertaining, humorous (even slightly satirical) exploration: not only of a possible future, but also of our rapidly changing present relationships with other people and technology. Discerning readers will be compelled to utilize their imaginations, again and again, in an attempt to depict the Psychology of the Future, which looks to be significantly different from anything Freud might have considered.

To quote the visionary writer J.G. Ballard, "Sex times technology equals the future." Just as almost nobody predicted the Internet until it suddenly seemed to have ensnared all within its grasp, so the technology of AI may, sooner than we think, come to be as natural as breathing, and inevitably, perhaps deeply, ensconced in our unconscious -- to be revealed in our dream life as we fall asleep at night.

Dreams reveal truths far beyond what the rational mind might consider "tolerable." It is only at the borders of acceptability where our future freedoms reveal themselves, adumbrating and perhaps incubating a society of the future, where science and art seamlessly integrate themselves, and where poetry and technology are no longer alien domains but a vast cultural continuum where play and discovery create new language and, ahem, acceptable behaviors! We shall see...

Amazon books

Here's a strange thing.
Due to the store's settings of my laptop, I often see on my opening page alleged news items separated by
advertisings for products. Nothing new there. But I noticed one of the UK-orientated adverts showing a couple
of houses with white cliffs -presumably Dover's cliffs, and offering insurance or something.



But I'd seen the image before in TV commercials and so I went to look it up. It's called 'Seven Sisters' based
on the number of spits or promontories of the white cliffs. So the next thing to do was check it out on Google
Maps and as I perused the area around Seven Sisters, I noticed this strange monolith...



It doesn't show on the map and the megalith can only be seen in one capture position. I've scoured the internet
for any indication of it, but it seems unknown!
WTF? comes to mind!


Here's the link to the area of  the actual map

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Like most Americans, I will celebrate the 4th the same as we always have.

We already have our Tree of Liberty up and decorated.  It's been watered with the blood of British tyrants (symbolically, thanks Nigel for your sacrifice) and we'll have hot dogs by the fireplace for Uncle Sam to eat when he comes down the chimney and places presents under the tree so in the morning, we will awaken to gifts of Freedom!



How will you spend yours?

PSA in the event you or someone you know is taking these.


https://www.eurekalert.org/news-releases/993725

Quote:Peer-Reviewed Publication

UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS


Benzodiazepine use and discontinuation is associated with nervous system injury and negative life effects that continue after discontinuation, according to a new study from researchers at the University of Colorado Anschutz Medical Campus.

The study was published today in the journal PLOS One.

“Despite the fact that benzodiazepines have been widely prescribed for decades, this survey presents significant new evidence that a subset of patients experience long-term neurological complications,” said Alexis Ritvo, M.D, M.P.H., an assistant professor in psychiatry at the University of Colorado School of Medicine and  medical director of the nonprofit Alliance for Benzodiazepine Best Practices.“This should change how we think about benzodiazepines and how they are prescribed.”

“Patients have been reporting long-term effects from benzodiazepines for over 60 years. I am one of those patients. Even though I took my medication as prescribed, I still experience symptoms on a daily basis at four years off benzodiazepines. Our survey and the new term BIND give a voice to the patient experience and point to the need for further investigations,” said Christy Huff, M.D, one of the paper’s coauthors and a cardiologist and director of Benzodiazepine Information Coalition.

The survey was a collaborative effort between CU Anschutz, Vanderbilt University Medical Center, and several patient-led advocacy organizations that educate on benzodiazepine harms. Several members of the research team have lived experience with benzodiazepines, which informed the survey questions.

Symptoms were long-lasting, with 76.6% of all affirmative answers to symptom questions reporting the duration to be months or more than a year. The following ten symptoms persisted over a year in greater than half of respondents: low energy, difficulty focusing, memory loss, anxiety, insomnia, sensitivity to light and sounds, digestive problems, symptoms triggered by food and drink, muscle weakness and body pain. Particularly alarming, these symptoms were often reported as new and distinct from the symptoms for which benzodiazepines were originally prescribed. In addition, a majority of respondents reported prolonged negative life impacts in all areas, such as significantly damaged relationships, job loss and increased medical costs. Notably, 54.4% of the respondents reported suicidal thoughts or attempted suicide.

BIND is thought to be a result of brain changes resulting from benzodiazepine exposure. A general review of the literature suggests that it occurs in roughly one in five long-term users. The risk factors for BIND are not known, and more research is needed to further define the condition, along with treatment options.

"I don’t think we’ll ever get to the 2024 election. Things will implode in Washington before that...I also think that the levels of violence and criminality in our cities is so high that it is going to spill over into other places in society. People that normally think they can live remote from the problem are now beginning to be touched by the problem."
— Colonel Douglas Macgregor

Macgregor discusses the impending implosion in America & why we have all these growing problems on the world's stage, he sees China of little militarily threat for now, insight on Russia/Ukraine & the war, the woke military, the Trump Tape. Really interesting discussion on serious issues along with some thought provoking history. Not so sure I can believe all his commentary and he comes across as a no BS kind of guy, however a lot resonated with my views. It's just over 2 hours and found the more interesting discussion start around the 50 min mark.

Surprise, proof the CDC covered up covid vaccine cause of death. Pretty long article showing a few. Good information and clearly shows what most of us already knew about vaccine caused deaths.


https://brownstone.org/articles/cdc-alte...tificates/

Quote:[b]The FRAUD:[/b]


With that introduction, below are 7 death certificates from Minnesota that identify a covid vaccine as a cause of death where the CDC omitted the corresponding ICD 10 code identifying a vaccine side effect when the CDC assigned ICD codes to the death certificates.


Vaccine adverse events were denied – with maximum prejudice and then some – for many months before the medical mainstream has finally (begrudgingly) started to acknowledge that the covid vaccines can trigger potentially lethal pathologies (in exceedingly rare instances to be sure).


The clustering of death certificates mentioning a covid vaccine at the beginning of the rollout suggests that ‘administrative’ interference likely played a role in discouraging coroners from mentioning a covid vaccine on death certificates.

Another noteworthy tidbit here is the age of the decedents: every single one is a senior citizen, and the average age of the decedents is 80. This is important to highlight because whereas young people “dying suddenly” stands out, there has been much less attention or acknowledgement of the covid vaccine’s devastating toll upon the old and frail, where deaths – even those that occur in close proximity to vaccination – are readily attributed to prior health conditions.

Finally, the actions of the CDC call into question whether the CDC is altogether qualified or trustworthy enough to be the steward of the nation’s epidemiological data. The CDC manages many of the datasets that underpin whole fields of study.

If the CDC is willing to fraudulently alter data (or even if the CDC is just too incompetent to avoid corrupting data), all data under the aegis of the CDC is potentially suspect, especially if it relates to a controversial political or social issue. The implications of this are disturbing, to say the least.

Looks like China is going to cut us off because we are too stupid to mine, refine, produce, and manufacture key "Critical Infrastructure" and medicine here in the US.

https://dailycallernewsfoundation.org/20...for-chips/

Quote:China has implemented export limits on two metals utilized in the manufacturing of computer chips and other valuable technological devices, according to an announcement by the country’s Ministry of Commerce on Monday.


The export restrictions on gallium, germanium and their corresponding chemical compounds will officially take effect at the beginning of August, according to the announcement.  The controls may increase expenses for hardware producers and exacerbate geopolitical tensions surrounding the competition for groundbreaking computing technology, according to Bloomberg.

In addition to computer chips, manufacturers use gallium and germanium for a vast array of devices including solar panels, lasers and night vision goggles, according to Bloomberg. China is the primary producer of these metals based on its portion of worldwide mining and exporters will require a license to export them, according to the announcement.

The U.S. also relies on China for medical supply chains and the CEO of U.S. defense contractor Raytheon technologies told the Financial Times it would be impossible to break all ties with China.
President Joe Biden’s administration is weighing limits on U.S. exports of artificial intelligence chips to China, The Wall Street Journal reported. Similarly, they would require exporters to have a license.
This move would follow measures the Biden administration implemented in October to curb U.S. chip sales to China that could  benefit the Chinese military, according to the WSJ.

The China Academy of Engineering Physics (CAEP), the country’s primary nuclear weapons research institute, obtained American chips despite the export restrictions, the WSJ reported in January. CAEP has purchased the technology at least 12 times over the past two and a half years.

Appears Army standards no longer exist. I saw this story and my jaw dropped. 

Obviously Obese, In a role that requires a TS/SBI clearance and there is no way that could be achieved with the mental health issues talked about. Neck is way to small to even think about passing a tape test. I would highly doubt that they could pass a PT test. Hell, I would drop a K to bet they could not pass a PT test.

This is today's Army? 

I would be pissed if I were one of those who got chaptered for being a weight lifter for not passing weight / tape test.

https://www.army.mil/article/267818/livi...diers_life

I found myself the guest of the Saudi Kings Khalid and Fahd back in '82. I got to see what the Before People were able to create (at their expense) in Egypt. Later, I got myself a job that came with paid vacations to anywhere and traveled extensively in Central and South America for as much as a month at a time. I maybe regret not being formally trained in Archeology, but if I had, maybe my mind wouldn't have been so open to the things I was seeing with my own eyes.

I'd tell you the Pyramids are just shocking to see the first time. When you look at the Sphinx, there's no doubt some bastard ruined what it had been to have his tiny little head carved onto it. But, it's the other 'attractions' there that are the most fascinating. There's so much more going on there.

If someone asks, "Who do you think built that?" My answer most always comes back, "People who could."

We want to believe people could do it again, but we can't. I don't think we've achieved as much during this cycle of civilization as the last one (or the ones before) were able to come up with.

I remember reading once that if almost every human on the planet died tonight ... in about a thousand years ... if another group of humans came together and organized, they wouldn't be able to see what we've managed to do in 'our time'. That the erosion would leave behind so little, the only things that would indicate an advanced society had existed before them would be radioactive piles that don't naturally occur.

So what if ... the demises of mankind are not strictly based on climatological change (ice ages or meteor strikes or solar phenomena)? What if we share this planet with a more advanced intelligent life? And, what if that intelligence periodically wipes us out, as we become a threat to it?

I started to put this in the "Tucker is no Longer at Fox" but this is one of the harder hitting discussions on vaccines, government, and the hit pieces that have come out on JFK Jr. along with wire taps by NSA and others in this pitiful excuse for the land of the free home of the roll over for your master. He also covers some of the UFO stuff and traumatic brain injury by some of our service members who have had a close encounter with a UFO. Of course the government does not want to acknowledge the event even happened.