Aging

[quintessentone]

I am interested in the aging process and try to keep up on the latest longevity findings. This one caught my attention because magic mushrooms seem to be able to delay aging for a time in mice in this pre-clinical study. How it will act on humans is yet to be determined.

"Magic mushrooms rewind aging in mice—could they do the same for humans?"

"A surprising discovery from Emory University shows that psilocin, the active metabolite of psychedelic mushrooms, can delay cellular aging and extend lifespan. Human cells lived over 50% longer, and mice treated with psilocybin not only lived 30% longer but also looked and aged better.

"Emory is actively involved in Phase II and III clinical trials of psilocybin-assisted therapy for depression, and these results suggest we also need to understand psilocybin's systemic effects in aging populations," says Zarrabi. "My hope is also that if psilocybin-assisted therapy is approved as an intervention for depression by the FDA in 2027, then having a better quality of life would also translate into a longer, healthier life."

https://www.sciencedaily.com/releases/20...223838.htm
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Fascinating!

[Freija]

I'm already pretty old but send me a goodly sized stash of shrooms and I'll let you know how it goes.

[midicon]

I am interested in the aging process and try to keep up on the latest longevity findings. This one caught my attention because magic mushrooms seem to be able to delay aging for a time in mice in this pre-clinical study. How it will act on humans is yet to be determined.

"Magic mushrooms rewind aging in mice—could they do the same for humans?"

"A surprising discovery from Emory University shows that psilocin, the active metabolite of psychedelic mushrooms, can delay cellular aging and extend lifespan. Human cells lived over 50% longer, and mice treated with psilocybin not only lived 30% longer but also looked and aged better.

"Emory is actively involved in Phase II and III clinical trials of psilocybin-assisted therapy for depression, and these results suggest we also need to understand psilocybin's systemic effects in aging populations," says Zarrabi. "My hope is also that if psilocybin-assisted therapy is approved as an intervention for depression by the FDA in 2027, then having a better quality of life would also translate into a longer, healthier life."

https://www.sciencedaily.com/releases/20...223838.htm
----

Fascinating!

I've taken magic mushrooms a few times in my life and have always felt they changed me in some way. I took them, not for depression but really just for a trip...and also of course because I have always been into the esoteric.

Each time I took them, I had a little sort of snapshot dream that gave me insight into myself.

[quintessentone]

I'm already pretty old but send me a goodly sized stash of shrooms and I'll let you know how it goes.

 Well it is purported to be able to slow aging...do you want to live longer where your seratonin levels will give you emotional stability (just not giving a shit?) and a chill mood?

Our bodies have receptors in place for this!

"Psilocybin, the active compound in magic mushrooms, shows promising potential to slow aging through its interaction with serotonin receptors, particularly the 5-HT2A receptor, which is present in various cell types throughout the body including fibroblasts, neurons, heart cells, and immune cells"

https://agemed.org/e-journal/age-managem...er-2025-2/

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I am interested in the aging process and try to keep up on the latest longevity findings. This one caught my attention because magic mushrooms seem to be able to delay aging for a time in mice in this pre-clinical study. How it will act on humans is yet to be determined.

"Magic mushrooms rewind aging in mice—could they do the same for humans?"

"A surprising discovery from Emory University shows that psilocin, the active metabolite of psychedelic mushrooms, can delay cellular aging and extend lifespan. Human cells lived over 50% longer, and mice treated with psilocybin not only lived 30% longer but also looked and aged better.

"Emory is actively involved in Phase II and III clinical trials of psilocybin-assisted therapy for depression, and these results suggest we also need to understand psilocybin's systemic effects in aging populations," says Zarrabi. "My hope is also that if psilocybin-assisted therapy is approved as an intervention for depression by the FDA in 2027, then having a better quality of life would also translate into a longer, healthier life."

https://www.sciencedaily.com/releases/20...223838.htm
----

Fascinating!

I've taken magic mushrooms a few times in my life and have always felt they changed me in some way. I took them, not for depression but really just for a trip...and also of course because I have always been into the esoteric.

Each time I took them, I had a little sort of snapshot dream that gave me insight into myself.

I'm reluctant to try it, why? I don't know. But every shroom experience story I've heard so far is always positive even though some went too deep into it and were zombie like at times.

[midicon]

To be fair anyone I took them with said they would never do that with me again lol.

Really because back in those days I was the only one into the magic side of things.

I can't recommend taking them though as it might depend on your mindset. I think they are a good positive thing though.

I should add...The first time, I was 31 years old and really into Jungian psychology at that time.

[quintessentone]

To be fair anyone I took them with said they would never do that with me again lol.

Really because back in those days I was the only one into the maggic side of things.

I can't recommend taking them though as it might depend on your mindset. I think they are a good positive thing though.

Yes, that's the trick having a good positive mindset, where it that when it's at home? My mind is swamped with the good, bad and ugly of living seven decades and it's a gamble what will come forward during the shroom tripp'n.

Although, I wonder if just a nibble will give the delayed aging benefits rather than a full tripp'n dose.

[midicon]

To be fair anyone I took them with said they would never do that with me again lol.

Really because back in those days I was the only one into the maggic side of things.

I can't recommend taking them though as it might depend on your mindset. I think they are a good positive thing though.

Yes, that's the trick having a good positive mindset, where it that when it's at home? My mind is swamped with the good, bad and ugly of living seven decades and it's a gamble what will come forward during the shroom tripp'n.

Although, I wonder if just a nibble will give the delayed aging benefits rather than a full tripp'n dose.

When I say 'I had a little snapshot dream', that wouldn't occur until maybe a week later. I remember every one of those and it was very strange.

I think you could maybe have a small dose and reap benefit though.

[quintessentone]

To be fair anyone I took them with said they would never do that with me again lol.

Really because back in those days I was the only one into the maggic side of things.

I can't recommend taking them though as it might depend on your mindset. I think they are a good positive thing though.

Yes, that's the trick having a good positive mindset, where it that when it's at home? My mind is swamped with the good, bad and ugly of living seven decades and it's a gamble what will come forward during the shroom tripp'n.

Although, I wonder if just a nibble will give the delayed aging benefits rather than a full tripp'n dose.

When I say 'I had a little snapshot dream', that wouldn't occur until maybe a week later. I remember every one of those and it was very strange.

I think you could maybe have a small dose and reap benefit though.

Interesting, whether or not one's sub or middle conscious were poked?

What do you think of the dose given to mice and how much would an average human need to take?

"Results indicated that the mice that received an initial low dose of psilocybin of 5 mg, followed by a monthly high dose of 15 mg for 10 months, had a 30% increase in survival compared to mice that did not receive any. These mice also displayed healthier physical features, such as improved fur quality, fewer white hairs and hair regrowth." (from my source on page 1)

"5 mg is approximately 0.001 teaspoon when assuming the substance has a density similar to water (1 g/mL)."

"A typical house mouse weighs about 0.02% to 0.07% of the average human’s body weight."

"15 milligrams (mg) is approximately 0.003043 US teaspoons, assuming the substance has a density similar to water"

So doing the math:

Avg. human (North America) say 150 pounds
Mouse weight in grams, say 25 grams taking 15 mg high dose, so 0.06 =%

Human @ 68038.86 grams would taking 0.06%
would be 40.82 grams, which is an avg. of 8 teaspoons of shroom needed to delay aging ?

Did I do that math right?

[midicon]

I did edit my first reply to say that I was 31 the first time I took them. I had for the first time got a hold of two 'acid flints' and someone offered to swap them for some mushrooms. They were dried out and wrapped in a piece of kitchen roll, perhaps about a dozen or so. I took them with a girl and we stayed up alternating between laughing and feeling sick. Then a week later I had a strange little dream.

The other times they were freshly picked and I'd just lob them in a cup and make 'mushy tea'. I never weighed or concerned myself too much with the amount. I had a friend though who would dry them out and once in a blue moon, on a special occasion, would put a teaspoonful in a cup of tea.

I would think one teaspoon would be enough for you although maybe not for the 'aging' benefit. I think people are different though and they seemed to work on me in a weird way if that makes sense.

So six times and six little inner visions.

I should add that the first time was the only time ever I felt sick.

[babushka]

I absolutely hate mushrooms, no idea how you enjoy it or why people take it willingly.

[rickymouse]

I'm not interested in doing magic mushrooms to extend my life.  I actually do not think it is the psychoactive part that does that either.  There are other ways to reverse aging.

When we get older our bodies seem to slow down to extend our lifespan.  Now multiple foods can create that effect, but they don't make you high.  There are quite a few chemicals in food that have similar structure, the five and the six sided rings with legs on them with some chemicals on them but are not quite as strong.  Mixing of food chemistries can make us have an anti-inflammatory response which can result in building telomeres.  Stimulating telomerases while lowering inflamation will add telomeres to the Chromasomes....but there is a special combination that is needed.  I studied that a while back, but do not remember what needed to be done, and that would require a decent length of special diet to accomplish any real long term benefit.  Maybe shrooms are just more potent or something.

Lowering your consumption of ultra processed food and balancing the diet would be the best way to accomplish extending the lifespan.  I did research about five years ago after reading a research article that addressed genetic variants and life span, I researched diet integrated into genetic snps to try to figure out how to increases lifespan...by looking up certain snps in my DNA, I compared them to what they said is appropriate for long life.  My expected lifespan was estimated at 120 years, the wife's was 140 by their formula, but since our diet for many years contained lots of ultraprocessed foods so I am lucky that we are as old as we are.

If they do not fix the western diet and lower the chemicals added to food or our environment, our grandkids and great grandkids might not live over forty, expecially plastic in food, one research article noted that after twenty years of consuming it it effected the brain causing dementia like symptoms.  That article is one that stated it appears to be time, not age that might be causing dementia from plastic exposure which now they say is about the amount of plastic in a small plastic spoon in people's brains...which will also effect health and longevity since disrupting signals will give inappropriate immune responses...the brain is tied to everything.

Unless magic mushrooms remove the plastic from the brain, they are not going to fix things, people will die before they hit seventy, people with dementias have accidents more often trying to act like a teenager.  Many meds also block choline which is a neurotransmitter, which will lead to improper metabolic function and immune response.

Although, maybe if you eat shrooms you may piece everything together and eat less of the poisons in foods....maybe it will heighten your senses so you avoid the toxins.

I don't know how that research was done, there was no method of action listed in the article...in other words, it is a correlation, not a cause and effect yet....shrooms heighten our senses by increasing neurotransmiter receptor activation or something like that from my studies years ago.  Many psychedelics use methyl chemistry to heighten our mind.   That would be CH3 chemicals bonded to things, the easier they are to break off the more psychoactive.   That five sided tied to a six sided ring looks like a purine ring to me. Kind of looks like a bug to me, with legs sticking out.  I wonder if the magic mushrooms give people gout if they get gout.

I really should stop studying this stuff, most people do not know what I am talking about.  My mind wanders to ideas of how things might effect us, and I have to go look for research to see if my applications are correct.  Most times now, my application is mostly or completely correct when I go search for scientific studies....strangely, it seems everything I contemplate is already researched.....meaning I am not the first one to think about this relationship between things.

Actually I do not break down methyl well, so maybe I am high all the time. but nicotine and nicotinic acid help to keep me from having side effects by combining with the caffeine and creating Ammonia....kind of like how meth people get rid of the meth in their system for blood tests....nicotine also does the same thing to ethyls....the antidote for being drunk too.

[Freija]

My last shroom experience was about 4 years ago so I guess I was 67 at the time and it wasn't the best of nights. Ended up being the beginning of the end of the relationship between myself and what was my best friend of several years.

So the bar closes at 2:00 and her, I and her new boyfriend go to my place to keep the party going which was our regular weekend routine. Sometimes 4 or 5 others would join but this night it was just the three of us and her and I were planning to do some shroomin' with the bf not partaking because he was on probation and being piss tested every week.

He brews up a tea for us and before long we're feeling it, having a good time and rocking out taking turns playing music videos on the big screen piped through my beefy hi-fi rig and everything is fun and mellow and going well. I'm pleasantly hallucinating and apparently so was she because from out of nowhere she stands up and says they're leaving and accuses me of hitting on her boyfriend.

I was stunned and totally taken by surprised to say the least. Yeah, her bf was an attractive lad but Jeezus, he was 25 years younger than me so her observations were preposterous and unfounded.

I was totally peaking at this point and wasn't thrilled to be left alone but there I was. I was a bit upset at first but the whole thing was outrageously stupid so I quickly forgot about it and just enjoyed myself for the next few hours until after the sun came up and I had come down enough to crash.

No profound revelations or deep introspective cosmic awakenings were to be had. As someone that had tripped probably 200 or more times on LSD in my 20s there wasn't much left to discover.

Other than the weirdness, it was more visual than I anticipated and not so much of the out-of-body experience. I have not done them since and don't even use cannabis that much anymore because I've totally withdrawn from social life where I used to get it and am too lazy to go to a dispensary and stand in line.

Yeah, I'm bad. I'm a Rogue! 

PS!
My friend and I worked it out and things were okay for a while but she settled down, had two babies in a row and we drifted apart. I still hear from her every six months or so but really don't care.

[David64]

To be fair anyone I took them with said they would never do that with me again lol.

Really because back in those days I was the only one into the maggic side of things.

I can't recommend taking them though as it might depend on your mindset. I think they are a good positive thing though.

Yes, that's the trick having a good positive mindset, where it that when it's at home? My mind is swamped with the good, bad and ugly of living seven decades and it's a gamble what will come forward during the shroom tripp'n.

Although, I wonder if just a nibble will give the delayed aging benefits rather than a full tripp'n dose.

When I say 'I had a little snapshot dream', that wouldn't occur until maybe a week later. I remember every one of those and it was very strange.

I think you could maybe have a small dose and reap benefit though.

Interesting, whether or not one's sub or middle conscious were poked?

What do you think of the dose given to mice and how much would an average human need to take?

"Results indicated that the mice that received an initial low dose of psilocybin of 5 mg, followed by a monthly high dose of 15 mg for 10 months, had a 30% increase in survival compared to mice that did not receive any. These mice also displayed healthier physical features, such as improved fur quality, fewer white hairs and hair regrowth." (from my source on page 1)

"5 mg is approximately 0.001 teaspoon when assuming the substance has a density similar to water (1 g/mL)."

"A typical house mouse weighs about 0.02% to 0.07% of the average human’s body weight."

"15 milligrams (mg) is approximately 0.003043 US teaspoons, assuming the substance has a density similar to water"

So doing the math:

Avg. human (North America) say 150 pounds
Mouse weight in grams, say 25 grams taking 15 mg high dose, so 0.06 =%

Human @ 68038.86 grams would taking 0.06%
would be 40.82 grams, which is an avg. of 8 teaspoons of shroom needed to delay aging ?

Did I do that math right?

Maybe try micro dosing first. Not a "take a trip" dose, but an amount that works on a sub conscious level and see how it goes from there.

[The Crying Bunny]

Liberal tears keep me alive.

[727Sky]

Liberal tears keep me alive.

Well it does give us something to live for so I agree. 

I am weird in that I am not interested in getting high or changing moods by chemical means. Yes there are plenty of folks who can not go a day without wine or a beer or a smoke or a ETC ETC.. 

I have seen to many of my band mates and childhood friends end up with less than good lives because alcohol, drugs, or chasing their next fix; almost all are dead now.. To each his own as I figure "natural selection" is alive and well.

Anything that can extend the telomeres of your cells without causing cancer is probably a good bet for life extension.

[Freija]

Liberal tears keep me alive.

Was anyone here crying except maybe you, sad rabbit? Your source of sustenance seems rather lacking? Try some carrots or lettuce instead of emotional vampirism. You'll feel fuller and be more regular.

[727Sky]

the silent assassin 

[quintessentone]

A big thank you for all the replies, a little overwhelming though. Except the crack about liberal tears, from what I'm seeing it is liberal tears of happiness. 

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It seems delayed aging comes down to lengthening telomeres, but it's not so much the delayed aging I am after, rather just feeling like my old self.

I'm already doing a lot of what is recommended below to just be as healthy as I can, but I am also after that youthful vigor that has somewhat slipped away.

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"To lengthen telomeres, focus on lifestyle changes and targeted interventions supported by scientific research:
Reduce Stress: Chronic stress shortens telomeres. Practices like mindfulness meditation, yoga, and regular relaxation can lower cortisol levels and increase telomerase activity, the enzyme that maintains telomere length. 

Exercise Regularly: Both aerobic endurance training and high-intensity interval training (HIIT) are linked to longer telomeres.  Aim for at least 150 minutes of moderate to vigorous activity weekly, as physical activity reduces oxidative stress and inflammation. 

Eat a Telomere-Friendly Diet: Prioritize a plant-based diet rich in whole foods, including:

• Fruits and vegetables (especially leafy greens for folate)
  
• Nuts, legumes, and whole grains
  
• Omega-3 fatty acids (from flaxseed, chia, walnuts, or fish oil)
  
• Antioxidants like vitamins C and E, polyphenols, and selenium 
  
  

Avoid processed foods, red meat, and excess sugar, which are associated with faster telomere shortening. 

Get Quality Sleep: Aim for 7–9 hours per night. Poor sleep increases inflammation and oxidative stress, accelerating telomere shortening. Longer sleep duration is linked to longer telomeres. 

Consider Supplements: Some supplements may support telomere length by activating telomerase or protecting DNA:

• ac-11® (from cat’s claw extract)
  
• Astragalus root extract
  
• Vitamin D
  
• Omega-3 fatty acids
  
• L-citrulline
  
• Milk thistle seed extract 
  
  

Emerging Therapies: Experimental approaches like modified TERT mRNA (used in lab studies) can extend telomeres by over 1,000 nucleotides, but these are not yet safe or available for general use.  Similarly, metformin shows potential for telomere stability via metabolic regulation, but more research is needed. 

Caution: While telomere extension holds promise for longevity, uncontrolled activation of telomerase may increase cancer risk. Always prioritize proven, safe lifestyle strategies over unregulated supplements or experimental treatments.


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There's always a side effect and that one is a doozy.

[Kenzo1]

Step 1 :   Avoid toxic American food a la Bayer glyphosate & other toxic agents .

Step 2 :  Get enough all good nutrients .

Step 3 :  Exercise.


How much vitamin D you take ?, many are taking too low doses . Also taking D , A and K vitamins same time gives synergy boost . ( avoid synthetic vitamin A )  I am taking now 300mcg Vit D  plant-based source of Vitamin D3 from lichens

Taurine is anti aging .

Vitamin C should be the original real C and not the synthetic isolates ( i prefer acerola cherry powder )

[quintessentone]

Step 1 :   Avoid toxic American food a la Bayer glyphosate & other toxic agents .

Step 2 :  Get enough all good nutrients .

Step 3 :  Exercise.


How much vitamin D you take ?, many are taking too low doses . Also taking D , A and K vitamins same time gives synergy boost . ( avoid synthetic vitamin A )  I am taking now 300mcg Vit D  plant-based source of Vitamin D3 from lichens

Taurine is anti aging .

Vitamin C should be the original real C and not the synthetic isolates ( i prefer acerola cherry powder )

Yes, I've been hearing and seeing a lot of discussion on Vit. D and its benefits. Don't you have to combine Vit. D with a Calcium supplement for proper absorption by the body?

I take Vit. D, C and Potassium off and on but we eat very healthy. Because in the back of my mind, I think that I may be fooling myself into thinking I am getting what is needed from a combined raw vegetable, nut, feta cheese and seed salads (sort of a mediterranean salad on steroids) when the land these foods are grown on are devoid of the right kind of nutrients for plant uptake.

The exercise part is challenging, what with some issues slowing me down physically, but I try to incorporate deep breathing and stretching, with the occasional wall push up. However, come Spring I will be out gardening, which invigorates my love of nature and my body and soul.

I suppose I am more interested in not lengthening my life, but getting back to an acceptable level of what will allow me to continue to do what I love to do and I'm not sure that food and exercise holds all the keys to achieve that.

That is why I subscribe to longevity and aging science information in my feeds because who knows when the fountain of youth secrets will be revealed, without side effects.

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For your consideration, here's another take on aging from Neil De Grasse Tyson and Chuck Nice, who have some nuggets of truth when it comes to accepting the realities of aging. We can't turn back the hands of time but we can grow in new ways going forward.