HISTORY OF THE MEDICINAL USE OF TOBACCO/NICOTINE

[Kenzo1]

These are not easy things to know all rickymouse , human biology is  complicated   


I been trying to look/understand the vitamin B9 , as it is related to methylation & MTHFR   

It look`s somehow important to methylation but also to regulating histamines, maybe mast cells also . Then comes all the different forms , and opinions.... been using methyl version , but there is also folinic acid which i never tryed ...

I take the methyl version of Folate and avoid the folic acid supplements that are not methyl forms.  Folinic acid was in some of the combos I tried, and it is about the same as folate.    I have the A1298C double c that is my problem, it does not increase homocysteine levels, but coupled with other methylation doubles it can cause some problems.  One of those problems is increased risk of brain cancer...my father died from brain cancer, and his kind was related most likely to DDT he sprayed on some of the crops in the sixties before it was banned.  But this gene might have something to do with it too.  I do not have any copies of the problematic 677 that are a problem with homocysteine, and even one copy of the 1298 coupled with one 677 is worse than what I have.  So having a constant small amount of methylfolate each day helps to keep things better because I have a constant supply available to give me full time coverage all day long...at least that is what I think is going on since it helps me quite a bit.  I also do better with the methyl and adeno cobalamins but the cyano version occasionally doesn't hurt, but too long and the cyanocobalamin does drag me down in energy and thinking ability.  I have not tried the hydroxo version of cobalamin....I think you need a prescription for that and that is used for some kinds of poisoning.

I studied this intensively, many hundreds of research articles and studies talking about the methylation problems.  I cannot test things on myself to find solutions to problems caused by other genetic conditions others have, just the ones I have.

I have plenty of weird genes, I think that my wife married me because she loves cats and I share some genetic traits with cats....The molybdenum coenzyme is necessary to make sulfite oxidase, and the sulfite oxidase is necessary to make taurine in the liver, and also to utilize taurine in the body.  So that means since taurine can treat epilepsy, I also need molybdenum supplements to keep the seizure risk down.  Taurine is found in raw meat, and molybdenum is high in grasses that produce grains, like rye grass...cats like cat grass, it contains molybdenum and most likely the grass contains methylfolate which they also may need.  Rice also is rich in molybdenum, but because it is high in molybdenum the rice can contain arsenic and heavy metals, because molybdenum chealates metals well, Thiomolybdates are used to detox people in medicine for some kinds of poisoning, but also be cautious, if you have more molybdenum and you eat foods with arsenic, you might possibly take in more arsenic too.  Also take copper with molybdenum supplements or a person could get a deficiency in copper after a while which might make a person frail because copper is needed to make collagen.

There are hundreds of ways to interpret things, which makes it hard to explain and people have the idea if a little helps, a lot will do even better....too much medicine can cause problems, even tobacco is a medicine, it can cause problems if a person smokes too much...had to put that in to make it so I am not creating an off topic post.

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Surprising what you can learn by actually studying your problems that you learned you had from genetic apps. I knew from young that I was intolerant to breads...

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Have you tried researching your deep genetic ancestry to determine what they ate? By "deep" I don't mean 100 years ago, or even 200 years ago, but millennia ago. You won't have names for them, but you can find out where your genetic patterns came from most strongly.

I ask because back in the 1970's, I read a book by a doctor named Jethro Kloss. "Back to Eden" I think it was called. He was a doctor, but dabbled quite a bit in herbal medicine. He had a theory that your deep ancestry determined what food you were genetically predisposed to react well to. It sort of makes sense - back in those days, if they ate disagreeable stuff, they were more likely to die early and not pass on their genes, so the genes that got passed down to you were from the people who got along well with what they ate.

Sea peoples ate fish and seafood, pastoralists ate meat and milk and developed lactose tolerance to be passed on, etc. Some societies went heavier on greens, some went heavier on fruit, some went heavier on meat, and so forth, and those tolerances got passed on genetically.

As an example, my deep ancestors drank mostly water, mead, and beer. My metabolism, as it turns out, gets along pretty well with those things. They ate barley bannock, fish, maize, and red meat, and my constitution handles those pretty well, too. They DIDN'T eat fowl like chicken, and as it turns out, chicken, turkey, etc doesn't agree with me at all.

They also ate some stuff I'll never be able to even pronounce, much less ever be able to make.

Might be something to check into.

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I read Back to eden many years ago.  It was a good book. 

I have genetics related to the Inuit people.  It is paternal DNA but because lots of Finnish women have that genetics in Xs I have some of the full blown food necessities of the inuit...but not all.  I am only one point seven percent Inuit according to My Herritage, and it appears that is all in metabolism.  Only three percent of Northern European men have the paternal genetics of the Inuit....other than the Inuit of course, most of the inuit males have the paternal version if their fathers were Inuit.  But other than having minor shoveling on the back of my teeth, and big teeth with long canines that made me make a good vampire at Halloween when I was a kid, I don't look like the Inuit, other than when I go out in the sun a lot I turn really dark, and I am a dark Finn...my skin is darker than most of them.

It takes about four generations for a person to adapt to a new food without problems from my research, incorporating a little more in each generation.  Well look at the USA and what health science is doing, telling people to eat super foods.  It is causing more health issues than anything.  But they say science says it is healthier, yeah, the people in sardenia have been eating their local fish for thousands of years..warm water fish that contain more histamines than cold water fish.  The fish in warm water have adapted and increased Histadine and histamine in their tissues.  Tuna is a warmer water fish, and some people and cats can't eat much of it without having problems.

That guy was right, and I also found an earlier reference, in the bible, moses had to have the people lost in the desert...for forty years, a couple of generations to fix their craziness from changing their diet so fast.  Altering diet so fast could cause mental issues, I have genes for AIP porphyria, if I were to try being a vegan or vegetarian I would get crazy.  But I do need to have some veggies, just in moderation.  and they should be cooked most times.  Now AIP porphyria is also called swedes disease and is present in that whole area, because they did not have green veggies all year, they genetically adapted and the same goes for the inuit...oh wait, lots of scandanavian country women have inuit genes.  one copy is not as much  a problem of the genset, but double copies are.

I read today about folate related opinions , turns out that some people warn not to take methyl folate too much, or everyday .....it has to some people like bell curve effect....meaning people feel first good when starting taking it, and can feel good next week, but then start feel bad.   It means for some people they should only take it when feel bad or like exercise more....methyl folate has side effects , again for " some people"  other may feel ok to take it everyday . This varies between different people to some degree. But i think methyl folate can cause issues with too big dose or too often taken .

I am not sure my case, but my gut just says i have issue with it....either low or high....i been now taking b komplex 1-2 time a day...and it had methyl folate. So now i am pausing it for few day at least to see ......

I will probably try folinic acid as it is more gentle....

I dont know noothing about my genes, never done test , or methyl test either.

hydroxo version of cobalamin is what i have and use, it dont need prescription .