Cancer is back in the headlines.
Cancer Is Striking More Young People, and Doctors Are Alarmed and Baffled (archived from The Wall Street Journal; Jan 11, 2024)
Their "BMJ Oncology" link throws a 404. I believe this is the study they reference:
The cause is likely NOT to be any single common denominator. Most probably a whole host of poison variables from a multitude of environmental factors over the decades, various chemicals/toxins in our food, water, air, plus microplastics & nanoplastics / modern synthesized petroleum based products to skincare products, our clothing; various medicine/drugs, experimental therapies in Epigenetics and Euphenics, the Sun in relation to Earth's magnetic field (?) causing disruption/weakening of immune system; Various radio waves & EMF radiation that bombards us all 24/7 to varying degrees
Although empirical studies have yielded discrepant results, epigenetic modifications are thought to be a biological mechanism for transgenerational trauma. Epigenetic changes modify the activation of certain genes, but not the genetic code sequence of DNA. The microstructure (not code) of DNA itself or the associated chromatin proteins may be modified, causing activation or silencing.
Epigenetic is the study of heritable traits, or a stable change of cell function, that happen without changes to the DNA sequence. Such effects on cellular and physiological phenotypic traits may result from environmental factors, or be part of normal development. They can however, lead to cancer.
Some epigenetic changes can be transmitted through a process called transgenerational epigenetic inheritance.
Maybe there is a single common denominator (like all that nuke fallout from the 50s-60s) and maybe it's some strange part of natural(?) human evolution, directly and/or indirectly.
I doubt it's a 'baffling mystery' and the answers for now are locked up in Manhattan secrecy, though I'm no expert nor amateur in the medical/cancer field science realm, just sharing my humble 2 cents.
Quote:Cancer Is Striking More Young People, and Doctors Are Alarmed and Baffled
Cancer is hitting more young people in the U.S. and around the globe, baffling doctors. Diagnosis rates in the U.S. rose in 2019 to 107.8 cases per 100,000 people under 50, up 12.8% from 95.6 in 2000, federal data show. A study in BMJ Oncology last year reported a sharp global rise in cancers in people under 50, with the highest rates in North America, Australia and Western Europe.
Doctors are racing to figure out what is making them sick, and how to identify young people who are at high risk. They suspect that changes in the way we live—less physical activity, more ultra-processed foods, new toxins—have raised the risk for younger generations.
...
The U.S. cancer death rate has dropped by one-third since 1991, thanks to a plunge in smoking and better treatment. Screening to catch cancers earlier, including breast cancer, has helped, too.
Although cancer still strikes older people far more often than the young, the rise in early-onset cancers threatens to stall progress. One in five new colorectal cancer patients in 2019 was under 55, a near doubling since 1995. These younger patients are often diagnosed at late stages. Colorectal cancer death rates among patients over 65 are going down, but for those under 50 they are going up.
“We are seeing more and more young people who don’t fit the classic teaching that cancer is a disease of aging,” said Dr. Monique Gary, medical director of the cancer program at Grand View Health in Pennsylvania.
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The risk of developing some cancers at a young age has increased for each generation born since the 1950s, studies suggest. One found that people born in the 1990s are at double the risk for early-onset colon cancer and four times the risk for rectal cancer, compared with people born around 1950.
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Researchers are scrutinizing possible causes ranging from inactive lifestyles to microplastics. Oncologists have found a greater risk of developing colorectal cancer at a young age among women who spent a lot of time sitting in front of the TV. Drinking sugary drinks in high school correlated with higher risk, too. Even being born via caesarean section seemed to link another group of women with higher risk of getting colorectal cancer early.
Deep-fried and highly processed foods have been implicated in other studies of early onset colorectal cancer, while diets with fiber, fruits and vegetables likely lower risks. Cancers including colorectal, breast and pancreatic have been tied to obesity, and studies support a link between excess weight and some early onset cancers.
But doctors said obesity and lifestyle can’t fully account for the plight of the people arriving at their clinics.
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Some doctors suspect that cancer-causing exposures might have started during patients’ childhoods, something that is difficult to trace. Unlike when smoking drove up lung cancer deaths in the 20th century, doctors suspect there isn’t a single carcinogen responsible for the current trends. Some worry young people’s rising cancer risks are a sign of deeper trouble.
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Other cancer centers are tracking groups of patients over time. Doctors at Memorial Sloan Kettering are collecting tumor samples and asking young patients about exposure to possible risks, from alcohol to anxiety medication. They are probing patients’ origins, too: How old were your parents when you were born? Were you breast-fed?
Cancer Is Striking More Young People, and Doctors Are Alarmed and Baffled (archived from The Wall Street Journal; Jan 11, 2024)
Their "BMJ Oncology" link throws a 404. I believe this is the study they reference:
Quote:Global trends in incidence, death, burden and risk factors of early-onset cancer from 1990 to 2019Paper is too lengthy (with lots of charts/graphs) to quote anyone paragraph without loosing context.
Abstract
Objective This study aimed to explore the global burden of early-onset cancer based on the Global Burden of Disease (GBD) 2019 study for 29 cancers worldwid.
Methods and analysis Incidence, deaths, disability-adjusted life years (DALYs) and risk factors for 29 early-onset cancer groups were obtained from GBD.
Results Global incidence of early-onset cancer increased by 79.1% and the number of early-onset cancer deaths increased by 27.7% between 1990 and 2019. Early-onset breast, tracheal, bronchus and lung, stomach and colorectal cancers showed the highest mortality and DALYs in 2019. Globally, the incidence rates of early-onset nasopharyngeal and prostate cancer showed the fastest increasing trend, whereas early-onset liver cancer showed the sharpest decrease. Early-onset colorectal cancers had high DALYs within the top five ranking for both men and women. High-middle and middle Sociodemographic Index (SDI) regions had the highest burden of early-onset cancer. The morbidity of early-onset cancer increased with the SDI, and the mortality rate decreased considerably when SDI increased from 0.7 to 1. The projections indicated that the global number of incidence and deaths of early-onset cancer would increase by 31% and 21% in 2030, respectively. Dietary risk factors (diet high in red meat, low in fruits, high in sodium and low in milk, etc), alcohol consumption and tobacco use are the main risk factors underlying early-onset cancers.
Conclusion Early-onset cancer morbidity continues to increase worldwide with notable variances in mortality and DALYs between areas, countries, sex and cancer types. Encouraging a healthy lifestyle could reduce early-onset cancer disease burden.
Introduction
Globally, cancer is a significant cause of morbidity and mortality, resulting in a large disease burden.1 According to Global Cancer Statistics 2020, breast cancer with the largest number of 2.3 million new cases accounted for 11.7% of all cancers, followed by lung cancer (11.4%), colorectal cancer (CRC) (10.0 %), while lung cancer was the main cause of cancer death (1.8 million deaths, 18%), followed by CRC (9.4%), liver (8.3%) cancer.1 Cancer is generally more prevalent in adults over 50 years, but the incidence of early-onset cancer (<50 years) has increased worldwide.2 In comparison to later-onset cancer, the increase of early-onset cancer has significant personal and societal ramifications. Moreover, early-onset cancer and the adverse impacts of some corresponding cancer treatments may result in additional health issues during subsequent life cycle,3 which would considerably increase the disease burden associated with early-onset cancers.
...
The cause is likely NOT to be any single common denominator. Most probably a whole host of poison variables from a multitude of environmental factors over the decades, various chemicals/toxins in our food, water, air, plus microplastics & nanoplastics / modern synthesized petroleum based products to skincare products, our clothing; various medicine/drugs, experimental therapies in Epigenetics and Euphenics, the Sun in relation to Earth's magnetic field (?) causing disruption/weakening of immune system; Various radio waves & EMF radiation that bombards us all 24/7 to varying degrees
Although empirical studies have yielded discrepant results, epigenetic modifications are thought to be a biological mechanism for transgenerational trauma. Epigenetic changes modify the activation of certain genes, but not the genetic code sequence of DNA. The microstructure (not code) of DNA itself or the associated chromatin proteins may be modified, causing activation or silencing.
Epigenetic is the study of heritable traits, or a stable change of cell function, that happen without changes to the DNA sequence. Such effects on cellular and physiological phenotypic traits may result from environmental factors, or be part of normal development. They can however, lead to cancer.
Some epigenetic changes can be transmitted through a process called transgenerational epigenetic inheritance.
Maybe there is a single common denominator (like all that nuke fallout from the 50s-60s) and maybe it's some strange part of natural(?) human evolution, directly and/or indirectly.
I doubt it's a 'baffling mystery' and the answers for now are locked up in Manhattan secrecy, though I'm no expert nor amateur in the medical/cancer field science realm, just sharing my humble 2 cents.
"It is hard to imagine a more stupid or more dangerous way of making decisions than by putting those decisions in the hands of people who pay no price for being wrong." – Thomas Sowell
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